Roswell Park Memorial Institute 1640 Medium (RPMI)
^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
RPMI is a medium used in cell culture and was developed in 1966 at the Roswell Park Memorial Institute by Moore *et al.*:footcite:p:`Moore1967`. 
Its exact formulation is known and available via `ThermoFisher Scientific <https://www.thermofisher.com/de/de/home/technical-resources/media-formulation.114.html>`__\ :footcite:p:`11875RPMI1640`.

.. list-table:: RPMI composition
  :name: rpmi_comp
  :align: center
  :widths: 54 26
  :header-rows: 1
  :class: no-scrollbar-table

  * - name
    - source
  * - 3-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanamido]propanoate [Pantothenate]
    - D-Calcium pantothenate
  * - 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol [Pyridoxine]
    - Pyridoxine hydrochloride
  * - 4-Aminobenzoic acid
    - Para-Aminobenzoic Acid
  * - Biotin
    - Biotin
  * - Calcium(II) cation [Ca(2+)]
    - D-Calcium pantothenate, Calcium nitrate (Ca(NO3)2 4H2O)
  * - Carbon dioxide [CO2]
    - Carbon dioxide
  * - Hydrogencarbonate
    - Bicarbonate (NaHCO3)
  * - Chloride [Cl(-)]
    - L-Cystine 2HCl, L-Lysine hydrochloride, Choline chloride, Pyridoxine hydrochloride, Thiamine hydrochloride, Potassium Chloride (KCl), Sodium Chloride (NaCl)
  * - Choline
    - Choline chloride
  * - Cob(I)alamin
    - Vitamin B12
  * - Cob(II)alamin
    - Vitamin B12
  * - D-Glucose
    - D-Glucose (Dextrose)
  * - Dioxygen [O2]
    - Oxygen
  * - Glycine
    - Glycine
  * - Hydrogen [H(+)]
    - L-Cystine 2HCl, L-Lysine hydrochloride, L-Tyrosine disodium salt dihydrate, Pyridoxine hydrochloride, Thiamine hydrochloride
  * - L-Cystine
    - L-Cystine 2HCl
  * - L-Arginine
    - L-Arginine
  * - L-Asparagine
    - L-Asparagine
  * - L-Aspartate
    - L-Aspartic acid
  * - L-Glutamate
    - L-Glutamic Acid
  * - L-Glutamine
    - L-Glutamine
  * - L-Histidine
    - L-Histidine
  * - L-Isoleucine
    - L-Isoleucine
  * - L-Leucine
    - L-Leucine
  * - L-Lysine
    - L-Lysine hydrochloride
  * - L-Methionine
    - L-Methionine
  * - L-Phenylalanine
    - L-Phenylalanine
  * - L-Proline
    - L-Proline
  * - L-Serine
    - L-Serine
  * - L-Threonine
    - L-Threonine
  * - L-Tryptophan
    - L-Tryptophan
  * - L-Tyrosine
    - L-Tyrosine disodium salt dihydrate
  * - L-Valine
    - L-Valine
  * - L-gamma-Glutamyl-L-cysteinylglycine [Glutathione]
    - Glutathione (reduced)
  * - Magnesium(II) cation [Mg(2+)]
    - Magnesium Sulfate (MgSO4) (anhyd.)
  * - Myo-inositol
    - i-Inositol
  * - N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid [Folate]
    - Folic Acid
  * - Niacinamide
    - Niacinamide
  * - Nitrate [NO3(-)]
    - Calcium nitrate (Ca(NO3)2 4H2O)
  * - Phosphate [PO4(3-)]
    - Sodium Phosphate dibasic (Na2HPO4) anhydrous
  * - Potassium(I) cation [K(+)]
    - Potassium Chloride (KCl)
  * - Riboflavin
    - Riboflavin
  * - Sodium(I) cation [Na(+)]
    - L-Tyrosine disodium salt dihydrate, Sodium Bicarbonate (NaHCO3), Sodium Chloride (NaCl), Sodium Phosphate dibasic (Na2HPO4) anhydrous
  * - Sulfate [SO4(2-)]
    - Magnesium Sulfate (MgSO4) (anhyd.)
  * - Thiamine
    - Thiamine hydrochloride
  * - Vitamin B12
    - Vitamin B12
  * - Water [H2O]
    - Calcium nitrate (Ca(NO3)2 4H2O)
  * - trans-4-Hydroxy-L-proline
    - L-Hydroxyproline

.. footbibliography::